Tata Memorial Centre (ACTREC-TMC), India
I am a PhD graduate student in the Health sciences program at the Tata Memorial Hospital under the mentorship of Prof. Sudeep Gupta at the Clinical genomics and hypoxia lab, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre. I am a computational biologist by training and analyse big data generated from patient samples using OMICS technologies to integrate with, and inform, pre-clinical assays. The eventual goal of our laboratory is to translate our pre-clinical findings in the laboratory into relevant interventions addressing clinical problems. The primary focus of my PhD work in this laboratory is to understand mechanisms of disease spread in triple negative breast cancer (TNBC) via clonal evolution and expansion over the course of the disease. TNBC is an aggressive type of breast cancer characterized by the lack of expression of hormone receptors and subsequent high mortality rate. Our group has longitudinally sampled triple negative breast cancer TNBC patients while they undergo therapy, till mortality and subjected these clinical samples to big data OMICS technologies. We aim to identify genetic aberrations across the different clinical phases of the disease and re-construct their clonal architecture to identify dynamics of relapse and metastatic spread.